Predictive value of preoperative β3 adrenergic receptor expression level in peripheral blood lymphocytes for recurrence after atrial fibrillation radiofrequency ablation study
10.3969/j.issn.1671-8348.2025.11.021
- VernacularTitle:术前外周血淋巴细胞β3肾上腺素受体表达水平对心房颤动射频消融术后复发的预测价值研究
- Author:
Zisang ZHANG
1
;
Teng WANG
;
Fei YE
;
Xinyu YANG
Author Information
1. 昆山市第一人民医院心血管内科,江苏昆山 215300
- Keywords:
atrial fibrillation;
β3-adrenergic receptor;
radiofrequency ablation;
postoperative recurrence
- From:
Chongqing Medicine
2025;54(11):2605-2611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of β3-adrenergic receptor(β3-AR)expression levels for recurrence after radiofrequency ablation in patients with atrial fibrillation(AF).Methods Patients with AF who underwent their first radiofrequency ablation in the Department of Cardiology from January 2022 to February 2024(AF group,n=166)and healthy individuals undergoing routine medical check-ups during the same period(control group,n=100)were selected as study subjects.Based on whether AF recurred after the procedure during follow-up,AF patients were divided into a non-recurrence group and a recurrence group.General clinical data and relevant laboratory indices of AF patients were collected.The relative expression lev-el of lymphocyte β3-AR mRNA was measured using fluorescence real-time quantitative PCR.Multivariate lo-gistic regression analysis was used to identify risk factors for AF recurrence after surgery,and receiver operat-ing characteristic(ROC)curve analysis was employed to evaluate the predictive value of β3-AR mRNA ex-pression levels for AF recurrence after ablation.Results After 9 months of follow-up post-radiofrequency ab-lation,among 166 AF patients,42 experienced recurrence,with a recurrence rate of 25.3%.Compared with the non-recurrence group,patients in the recurrence group had significantly higher levels of sST2,IL-6 and left at-rial diameter(LAD),with a statistically significant differences(P<0.05).The relative expression level of β3-AR was higher in the recurrence group than in the non-recurrence group,with a statistically significant differ-ence(P<0.05).Multivariate logistic regression analysis showed that LAD,sST2,IL-6,and β3-AR were inde-pendent risk factors for AF recurrence after surgery(P<0.05).ROC curve analysis indicated that the area under the curve for β3-AR mRNA relative expression level in predicting AF recurrence after radiofrequency ablation was 0.884(95%CI:0.794 to 0.975;P<0.05).Conclusion High preoperative expression levels of β3-AR in AF patients are associated with recurrence after radiofrequency ablation,and β3-AR can serve as a potential biological marker for predicting AF recurrence.
