The impact of gestational hypertension disorders on the growth and development outcomes of premature infants with gestational age<32 weeks
10.3969/j.issn.1671-8348.2025.11.016
- VernacularTitle:妊娠期高血压疾病对胎龄<32周早产儿生长发育不良结局的影响
- Author:
Jiao YUAN
1
;
Xingxing YANG
Author Information
1. 银川市妇幼保健院新生儿科,银川 750001
- Keywords:
hypertensive disorders of pregnancy;
preterm infants;
growth and development;
hypothy-roidism;
cholestasis
- From:
Chongqing Medicine
2025;54(11):2577-2582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hypertensive disorders of pregnancy(HDP)on the adverse growth and development outcomes of premature infants with gestational age<32 weeks.Methods Premature infants with gestational age<32 weeks admitted to the neonatal intensive care unit of Yinchuan Maternal and Child Health Hospital General Hospital and Yuehai Branch from 2017 to 2024 were selected as the study sub-jects,and general information of premature infants and mothers was collected to analyze the relationship be-tween HDP and adverse growth and development outcomes in these infants.Results A total of 173 premature infants were included,including 88 males(50.9%)and 85 females(49.1%).There were 41 cases(23.7%)of small for gestational age infants(SGA)and 132 cases(76.3%)of non SGA infants.A total of 65 cases(37.6%)had HDP mothers and 108 cases(62.4%)had non HDP mothers.Among SGA premature infants,75.6%(31/41)had a mother with HDP,while among non SGA premature infants,25.8%(34/132)had a mother with HDP.Regardless of whether premature infants were born with SGA or not,compared with the non HDP group,the HDP group had a higher incidence of extrauterine growth retardation(EUGR),congeni-tal hypothyroidism(CH),and parenteral nutrition associated cholestasis(PNAC)(P<0.05).In non SGA premature infants,compared with the non HDP group,the HDP group had a higher incidence of metabolic bone disease(MBD),and the difference was statistically significant(P<0.05).Multivariate logistic regres-sion analysis showed that HDP was an independent factor affecting the occurrence of EUGR in SGA preterm infants(P<0.05).HDP was an independent risk factor for CH,EUGR,and PNAC in non SGA preterm in-fants(P<0.05).Conclusion Maternal HDP can increase the risk of EUGR,CH,and PNAC in premature in-fants with gestational age<32 weeks,and is associated with poor postnatal growth and development out-comes in offspring.
