The impact of peripheral blood inflammatory factors on the risk of aortic aneurysm and aortic dissection based on Mendelian randomization analysis
10.3969/j.issn.1671-8348.2025.11.013
- VernacularTitle:基于孟德尔随机化分析外周血炎症因子对主动脉瘤和主动脉夹层发生风险的影响
- Author:
Mao SUN
1
;
Junjian CHEN
;
Deshu YANG
;
Ming XIE
Author Information
1. 重庆市急救医疗中心/重庆市第四人民医院/重庆大学附属中心医院,重庆 400016
- Keywords:
aortic aneurysm;
aortic dissection;
inflammatory factors;
interleukins;
Mendelian randomi-zation
- From:
Chongqing Medicine
2025;54(11):2559-2565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic effects of 15 peripheral blood inflammatory factors on the risk of aortic aneurysm and aortic dissection.Methods According to the relevance,independence,and ex-clusion assumptions of Mendelian randomization,instrumental variables predicting C-reactive protein and 14 interleukins(ILs)were extracted from human genome-wide association study data.The associations between these 15 peripheral inflammatory factors and the risk of aortic aneurysm and aortic dissection were investiga-ted using two-sample Mendelian randomization methods,including inverse-variance weighting,MR-PRESSO,and MR-Egger methods.Multivariable Mendelian randomization was used to assess the interactions of these inflammatory factors in influencing disease risk.Cochran's Q test and the MR-Egger intercept were used to e-valuate the heterogeneity and horizontal pleiotropy of the instrumental variables.Results The results of the inverse-variance weighted method showed that increased IL-16 levels were nominally associated with a reduced risk of aortic dissection(OR=0.837,95%CI:0.726 to 0.964,P=0.014).Increased IL-16 and IL-31 levels were also nominally associated with a reduced risk of aortic aneurysm(OR=0.949,95%CI:0.901 to 0.999,P=0.048;OR=0.934,95%CI:0.879 to 0.993,P=0.029).Increased IL-17F levels were nominally associat-ed with an increased risk of aortic aneurysm(OR=1.128,95%CI:1.007 to 1.264,P=0.038).No other in-flammatory factors were found to be associated with the risk of these two diseases using the inverse-variance weighted method.The MR-PRESSO and MR-Egger methods supported the results of the inverse-variance weighted method.Cochran's Q test and MR-Egger intercept test did not detect significant heterogeneity or horizontal pleiotropy.Conclusion IL-16,IL-31,and IL-17F may be involved at the genetic level in the inflam-matory mechanisms underlying the occurrence and development of aortic aneurysms and/or aortic dissections.Among them,IL-16 and IL-31 may play protective roles in aortic aneurysms and/or aortic dissections,whereas IL-17F may have a pathogenic effect on aortic aneurysms.
