The effects of high intensity interval training on fatigue and prognosis in chronic obstructive pulmonary disease patients
10.3969/j.issn.1671-8348.2025.11.002
- VernacularTitle:高强度间歇运动对COPD患者疲劳感及预后的影响
- Author:
Fan PENG
1
;
Yuling TANG
;
Hui XIAO
Author Information
1. 中南大学湘雅医学院附属长沙医院呼吸与危重症医学科,长沙 410005
- Keywords:
chronic obstructive pulmonary disease;
high-intensity interval training;
fatigue sensation;
rehabilitation training;
prognosis
- From:
Chongqing Medicine
2025;54(11):2487-2491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of high-intensity interval training on fatigue sensation and prognosis in patients with chronic obstructive pulmonary disease(COPD).Methods Sixty patients with COPD treated in outpatient and inpatient departments of our hospital from January to December 2024 were enrolled and randomly divided into a control group and an experimental group using a random number table method,with 30 patients in each group.The control group received conventional rehabilitation training,while the experimental group received high-intensity interval training on the basis of conventional rehabilitation training.Before and after the intervention,the pulmonary function indices(forced expiratory volume in the first second(FEV1),FEV1/forced vital capacity(FVC),diffusing capacity of the lung for carbon monoxide(DLCO)),exercise capacity(6-minute walk test(6MWT),peak oxygen uptake,and load power),subjective fatigue sensation(Fatigue Severity Scale,FSS),and serum level of interleukin-6(IL-6)of the two groups were measured,and the number of acute exacerbations during the 12-week intervention was counted.Results Compared with pre-intervention levels,the post-intervention experimental group showed significant improvements in FEV1 absolute value,percentage of FEV1 to FVC,DLCO,6MWT,peak oxygen uptake,and load power,along with reduced FSS scores and IL-6 levels(P<0.05).In the control group,only load power changed significant-ly(P<0.05),while other indicators showed no significant improvement(P>0.05).The experimental group had fewer acute exacerbations than the control group.Correlation analysis revealed positive correlation be-tween FSS scores and IL-6 levels(r=0.47,P<0.01).Conclusion High-intensity interval training can im-prove fatigue status,pulmonary function,exercise capacity,and inflammatory levels in COPD patients while reducing acute exacerbation risk.Fatigue sensation scores may serve as a potential indicator for assessing COPD disease progression and prognosis.
