Research progress on molecular regulatory mechanism of RNA-binding proteins in HBV-related hepatocellular carcinogenesis
10.3969/j.issn.1671-8348.2025.10.036
- VernacularTitle:RNA结合蛋白在HBV相关性肝细胞癌发生中分子调控机制的研究进展
- Author:
Liye XU
1
;
Jianzhao HUANG
Author Information
1. 贵州医科大学临床医学院,贵阳 550004
- Keywords:
HBV-related hepatocellular carcinoma;
RNA-binding proteins;
hepatitis B;
liver cirrhosis;
biotherapy
- From:
Chongqing Medicine
2025;54(10):2443-2447,2480
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma(HCC)is characterized by high incidence and poor prognosis.Hep-atitis B virus(HBV)infection is one of its primary causes,with HBV-related HCC accounting for 70％-80％of all HCC cases.In addition to surgical resection,molecular biological therapy is increasingly important in HCC treatment.Recent advances in research technologies have led to growing evidence demonstrating that RNA-binding proteins(RBPs)play critical regulatory roles in HCC pathogenesis.Furthermore,RBPs partici-pate in the development and functional regulation of the immune system.Consequently,they are emerging as a focal point for novel therapeutic strategies in malignancies and autoimmune diseases.This review aimed to summarize the molecular regulatory mechanisms of RBPs in the pathogenesis of HBV-associated HCC.
