Research progress on pharmacological characteristics of remimazolam and the factors influencing its pharmacodynamic effects
10.3969/j.issn.1671-8348.2025.10.035
- VernacularTitle:瑞马唑仑药理特点及药效影响因素的研究进展
- Author:
Xinghe CHEN
1
;
Ai YAN
;
Mengyi TU
;
Lan LUO
;
Yi CHENG
;
Yaxi YANG
;
Jie CHEN
Author Information
1. 重庆医科大学研究生院,重庆 400016
- Keywords:
remimazolam;
sedation;
pharmacological characteristics;
pharmacodynamics;
influencing factors
- From:
Chongqing Medicine
2025;54(10):2437-2442
- CountryChina
- Language:Chinese
-
Abstract:
Remimazolam is a novel ultra-short-acting benzodiazepine characterized by rapid metabolism via hydrolysis by non-specific esterases.This mechanism enables fast onset and quick recovery,significantly shortening the duration of anesthesia and effectively reducing the risk of drug accumulation in the body.It ex-hibits high binding specificity for the γ-aminobutyric acid(GABA)receptor,leading directly to central nerv-ous system inhibition and producing a pronounced sedative effect.This profile offers a more precise and con-trollable approach to anesthesia in clinical practice.The safety and efficacy of remimazolam have been demon-strated across various clinical settings,including procedural sedation,induction and maintenance of general an-esthesia,and sedation in the intensive care unit(ICU).Its adverse effects are relatively infrequent and highly predictable,as substantiated by numerous clinical trials;however,the optimization of its dosing regimens re-quires further in-depth investigation.This review summarized the pharmacological properties of remimazolam and provides a detailed discussion on the impact of various factors on its pharmacodynamics.These factors in-clude basic patient characteristics(such as gender,age,obesity,hepatic and renal function,and circadian rhythms)and external influences(such as altitude and drug interactions).
