Clinical and pathological characteristics and diagnostic analysis of 6 middle-aged and elderly patients with pulmonary ciliated mucinous nodular papillary adenoma
10.3969/j.issn.1671-8348.2025.10.024
- VernacularTitle:6例中老年肺纤毛黏液结节性乳头状腺瘤患者的临床病理特征及诊断分析
- Author:
Haibo TIAN
1
;
Chong ZHANG
;
Zhen ZHANG
Author Information
1. 重庆大学附属涪陵医院病理科,重庆 408000
- Keywords:
ciliated muconodular papillary adenoma;
pathological features;
immunohistochemistry;
mo-lecular detection;
differential diagnosis
- From:
Chongqing Medicine
2025;54(10):2376-2380,2385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical and pathological characteristics of middle-aged and elderly patients with pulmonary ciliated muconodular papillary adenoma(CMPA).Methods Clinical and pathological data as well as follow-up information of 6 middle-aged and elderly patients with CMPA were collected and or-ganized.Tumor tissue samples were observed,and HE staining and immunohistochemical analysis were per-formed on the slices.Results The age range of onset for 6 patients was 55-74 years old,with a median age of 65 years old,and a male to female ratio of 1∶5.In terms of lesion location,there were 2 cases in the left lung and 4 cases in the right lung.CT scan showed that the tumor presents as ground glass nodules or single round solid nodules,with short spikes visible at the edges of some nodules.All patients underwent wedge resection of lung tissue for treatment.Histologically,tumors consist of a bilayer cell structure consisting of luminal epi-thelial cells(including ciliated cells and mucinous cells)and basal cells,forming an glandular or papillary mor-phology.Mucus deposition could be observed within and around the cavity.Immunohistochemical results showed that all cells expressed thyroid transcription factor-1(TTF-1)positively,focal positive expression of aspartic protease A(Napsin A),and no expression of cytokeratin 20(CK20);Basal cells expressed p63 and CK5/6,with lower expression of Ki-67.Molecular testing did not detect any clear gene mutations.Conclusion CMPA has a biological behavior that is either benign or low-grade malignant,and has a good prognosis.
