Evaluation of the therapeutic effect of dupilumab combined with 2％ cleboride ointment in the treatment of moderate to severe atopic dermatitis
10.3969/j.issn.1671-8348.2025.10.012
- VernacularTitle:度普利尤单抗联合2％克立硼罗软膏治疗中重度特应性皮炎的疗效评估
- Author:
Baojun ZHANG
1
;
Shuangxing FU
;
Xiaobo FANG
;
Yinhua PENG
;
Yaguang WU
;
Zhifang ZHAI
Author Information
1. 绍兴文理学院附属医院皮肤科,浙江绍兴 312000
- Keywords:
dupilumab;
kleborol;
atopic dermatitis;
serum biomarkers;
efficacy analysis
- From:
Chongqing Medicine
2025;54(10):2309-2312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of dupilumab combined with 2％cleboride ointment in the treatment of moderate to severe atopic dermatitis,as well as its impact on serological indica-tors.Methods A retrospective analysis was conducted on the clinical data of 67 patients with moderate to se-vere atopic dermatitis(AD)admitted to the Department of Dermatology of Shaoxing University Affiliated Hospital from March 2021 to December 2024.The study subjects were divided into an experimental group(n=35)and a control group(n=32)according to the treatment method.The experimental group was treated with Dupilumab injection and 2％Cleboride ointment,while the control group was treated with ebastine tab-lets and 2％cleboride ointment.Clinical and related serological indicators of patients after 16 weeks of treat-ment were collected,and the itch digital scale score,eczema area and severity(EASI)score,IL-4,IL-13 levels,and incidence of local skin adverse reactions were analyzed before and after treatment in both groups.Results The total effective rate of the experimental group after treatment was 94.29％(33/35),which was higher than the control group[53.13％(17/32)],and the difference was statistically significant(x2=12.862,P＜0.001).There was no statistically significant difference in symptom scores,IL-4,and IL-13 levels between the two groups before treatment(P＞0.05).After treatment,the symptom scores of the experimental group were lower than those of the control group,and the difference was statistically significant(P＜0.05).The lev-els of IL-4 and IL-13 in the experimental group were lower than those in the control group,and the difference was statistically significant(P＜0.05).The incidence of adverse reactions in the experimental group was 2.86％(1/35),significantly lower than the 34.38％(11/32)in the control group,and the difference was sta-tistically significant(x2=9.252,P=0.002).Conclusion The combination of dupilumab injection and 2％cleboride ointment is effective in relieving skin symptoms,regulating cellular immune function,reducing in-flammatory reactions,and minimizing local skin adverse reactions in patients with moderate to severe AD.It is worthy of clinical promotion and use.
