Experimental study of hepatic oval cells regulating tissue regeneration in human liver cirrhosis through Wnt/β-catenin pathway
10.3969/j.issn.1671-8348.2025.10.007
- VernacularTitle:肝卵圆细胞通过Wnt/β-catenin通路调控人肝硬化组织再生的实验研究
- Author:
Jinkai LI
1
;
Wentao QU
;
Zhenxia WANG
Author Information
1. 内蒙古医科大学附属医院第一临床医学院,呼和浩特 010000
- Keywords:
liver cirrhosis;
hepatic oval cells;
liver oval cells;
liver regeneration;
Wnt/β-catenin pathway
- From:
Chongqing Medicine
2025;54(10):2275-2281,2288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of hepatic oval cells(HOCs)regulating liver regener-ation through Wnt/β-catenin pathway in human liver cirrhosis.Methods Forty cases of Child-Pugh class A cirrhosis tissues and 10 cases of normal liver tissues were collected and divided into the normal liver tissue group,the liver fibrosis group,the mild cirrhosis group and the moderate cirrhosis group based on HE staining and the Laennec classification system.The expression of Wnt/β-catenin pathway,CyclinD1 and Jagged-1 in each group were detected and compared,and the mechanism of Wnt/β-catenin pathway in the regulation of liver regeneration by HOCs was explored.Results The expression of Wnt and β-catenin increased with the aggravation of liver cirrhosis(P＜0.05).In contrast,the expression of CyclinD1 and Jagged-1 decreased with the aggravation of liver cirrhosis(P＜0.05).The expression levels of Wnt and β-catenin were positively corre-lated with the number of HOCs per unit area(r=0.806,0.634,P＜0.01).Compared with the degree of liver cirrhosis,the expression of Wnt/β-catenin had greater influence on the number of HOCs per unit area,the ex-pression of CyclinD1 and Jagged-1,and the differences were statistically significant(P＜0.05).Conclusion Wnt/β-catenin pathway can promote the generation of HOCs in human liver cirrhosis and mediate liver regenera-tion.
