Role of esketamine in reducing postoperative cognitive dysfunction in elderly patients and its signaling pathway mechanisms
10.3969/j.issn.1671-8348.2025.09.037
- VernacularTitle:艾司氯胺酮在降低老年患者术后认知功能障碍中的作用及其信号通路探讨
- Author:
Weixun SHANG
1
;
Dongbin ZHANG
;
Hongxiu LU
;
Yongliang CHI
Author Information
1. 山东中医药大学附属医院麻醉科,济南 250014
- Keywords:
esketamine;
postoperative cognitive dysfunction;
elderly patients;
signaling pathways
- From:
Chongqing Medicine
2025;54(9):2213-2218,2240
- CountryChina
- Language:Chinese
-
Abstract:
Postoperative cognitive dysfunction(POCD)is the common postoperative complications in elderly patients,significantly affects their postoperative recovery and quality of life.With the intensification of population aging,how to effectively prevent and treat POCD has become an important topic in clinical re-search.Esketamine(ISLAT)serves as a new anesthetic drug and its potential in improving postoperative cog-nitive function has gradually attracted people's attention.Previous studies have shown that that esketamine can not only alleviate postoperative pain,but may also protect the neurons and reduce the incidence of POCD in elderly patients by regulating the balance of neurotransmitters and reducing inflammatory responses,and has potential clinical application value.However,the researches on the specific mechanisms of action and relat-ed signaling pathways of esketamine is still limited and requires further exploration.This article aims to inves-tigate the role of esketamine in reducing POCD in elderly patients and its related signaling pathway,clarifies the clinical usage strategy and precautions to provide a theoretical basis for clinical application.
