Research progress on mechanism of isopsoralen in treating osteoporosis through ROS and the FoxOs family
10.3969/j.issn.1671-8348.2025.09.035
- VernacularTitle:异补骨脂素通过ROS、FoxOs家族治疗骨质疏松机制的研究进展
- Author:
Songyi LIANG
1
;
Shiyu YI
;
Risu NA
;
Jian WANG
Author Information
1. 内蒙古科技大学包头医学院,内蒙古包头 014040;内蒙古自治区人民医院骨科中心,呼和浩特 010010
- Keywords:
osteoporosis;
isopsoralen;
reactive oxygen species;
forkhead box class o family member pro-teins;
signaling pathway
- From:
Chongqing Medicine
2025;54(9):2200-2206
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis(OP)is a systemic bone disease.In recent years,the researches both at home and abroad find that the oxidative stress(OS)phenomenon driven by the abnormal accumulation of reactive oxygen species(ROS)and pro-inflammatory mediators not only accelerates the differentiation and activation of osteoclasts,but also inhibits the formation of osteoblasts.At the same time,a family of fork-head box pro-teins O(FoxOs)that can regulate OS is found to play a key role in bone homeostasis.Activated FoxOs family can up-regulate the expressions of a series of target genes and play an anti-osteoporosis role,but in certain spe-cial circumstances,the activation of the FoxOs family can also lead to degenerative OP.With great progress in the study of isopsoralen(ISO),ISO is found to have antioxidant effect,which can remove excessive ROS and alleviate the damage of OS on bone cells.At the same time,ISO can enhance the FoxOs family activity by reg-ulating FoxOs family phosphorylation and acetylation levels,thus promote bone formation.This article re-views the action mechanisms of ISO in regulating OS,ROS and FoxOs family,as well as relevant therapeutic strategies targeting the PPAR-γ/Wnt signaling pathway in order to provide references for the prevention and treatment of OP,and improve the living quality of the patients.
