Research progress on Klotho protein in acute kidney injury
10.3969/j.issn.1671-8348.2025.09.032
- VernacularTitle:Klotho蛋白在急性肾损伤中的研究进展
- Author:
Huimeng LI
1
;
Xiangbo WANG
;
Danfang DENG
;
Shenhui LYU
;
Haohan HU
;
Xiaoqin WANG
Author Information
1. 湖北中医药大学中医学院,武汉 430061
- Keywords:
Klotho;
acute kidney injury;
regulate the renin-angiotensin-aldosterone system;
antioxida-tive stress;
anti-inflammatory;
modulation of cell death;
anti-fibrosis
- From:
Chongqing Medicine
2025;54(9):2179-2185
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury(AKI)is characterized by high morbidity,high mortality,high disability rate and high treatment cost,its pathological mechanism has not been fully elucidated and there is a lack of ef-fective treatment methods.Klotho,a kidney-specific protective protein,is mainly expressed in renal tubular ep-ithelial cells,regulates the AKI progression and mitigates the renal injury through multiple pathways,inclu-ding the regulation of the renin-angiotensin-aldosterone system(RAAS),antioxidant stress,anti-inflamma-tion,modulation of cell death and anti-fibrotic effects.At present,the Klotho-based strategies for AKI preven-tion and treatment remain in the preclinical stage,requiring further investigation.This article reviews the mo-lecular regulatory mechanisms of Klotho in AKI and its diagnostic and therapeutic potential,aiming to provide new idea for the pathological mechanisms and clinical translation of AKI.
