Optimal evidence summary of platelet implantation delayed management in patients with allogeneic hematopoietic stem cell transplantation
10.3969/j.issn.1671-8348.2025.09.030
- VernacularTitle:异基因造血干细胞移植患者PLT植入延迟管理的最佳证据总结
- Author:
Yang LI
1
;
Li LIU
;
Fengmei TAN
;
Xiaolei ZHAO
Author Information
1. 西南医科大学附属医院血液内科,四川泸州 646000
- Keywords:
allogeneic hematopoietic stem cell transplantation;
delayed platelet implantation;
evidence summary;
implantation management;
mesenchymal stem cells
- From:
Chongqing Medicine
2025;54(9):2165-2172,2178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically retrieve,evaluate and summarize the related evidences of plate-let implantation delayed management in the patients with allogeneic hematopoietic stem cell transplantation.Methods According to the"6S"model,the clinical decision systems,guidelines network,professional associa-tion websites and databases were retrieved to collect the evidences regarding the platelet implantation delayed management in the patients with allogeneic hematopoietic stem cell transplantation,the retrieval time limit was from the database establishment to May 2024.Two researchers independently conducted the quality eval-uation of the literatures,evidence extraction and evidence integration.Results A total of 17 articles were fi-nally included,including 1 guideline,2 clinical decisions,3 systematic reviews,5 expert consensus and 6 ran-domized controlled trials.A total of 24 pieces of evidences were summarized in 5 aspects,including the pre-transplantation evaluation and prevention,application of mesenchymal stem cells,thrombopoietic drugs man-agement,blood transfusion support and complication management such as bleeding.Conclusion The medical and care staffs should carry out the best evidence practice for platelet implantation delayed management in the patients with allogeneic hematopoietic stem cell transplantation by combining with the domestic clinical situa-tion to reduce the hemorrhage in multiple organ systems after transplantation and improve the survival quality.
