Clinical study on screening value of TCT combined with HPV DNA detection in cervical cancer
10.3969/j.issn.1671-8348.2025.09.022
- VernacularTitle:TCT联合HPV-DNA检测对宫颈癌的筛查价值临床研究
- Author:
Shanzhu CAO
1
;
Wenting CHEN
Author Information
1. 宁波市北仑区妇幼保健院妇科,浙江宁波 315800
- Keywords:
cervical cancer;
malignant tumor;
screening value;
human papillomavirus;
liquid-based thin-layer cytology test
- From:
Chongqing Medicine
2025;54(9):2122-2127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the application value of liquid based thin-layer cytology(TCT)com-bined with human papillomavirus DNA(HPV-DNA)detection in cervical cancer screening.Methods The clinical data of 195 patients with suspected cervical cancer undergoing cervical cancer screening in this hospital from June 2020 to June 2024 were retrospectively analyzed.All patients underwent TCT,HPV-DNA test and pathological diagnosis.The results of HPV-DNA and TCT single and combined test were compared with the pathological diagnosis results(gold standard)to analyze the application value of different methods in cervical cancer screening.Results The pathological diagnosis results showed that among 195 patients,34 cases(17.44％)were cervicitis,49 cases(25.13％)were CIN grade 1,56 cases(28.72％)were CIN grade Ⅱ,and 32 cases(16.41％)were CIN grade Ⅲ,and 24 cases(12.31％)were carcinoma in situ;among 195 patients,the HPV-DNA examination showed 49 positive cases and 146 negative cases,including 15 cases of CIN grade Ⅱand 15 cases of CIN grade Ⅲ,and 19 cases of cervical cancer;among 195 patients,NILM,ASCUS,LSIL,HSIL and SCC were detected by TCT examination in 29,30,48,64 and 24 cases,respectively.Among them,17 cases were correctly diagnosed as cervical cancer and 7 cases were misdiagnosed as HSIL;the diagnostic accu-racy,sensitivity,specificity,positive predictive value and negative predictive value of HPV-DNA examination for cervical cancer were 82.05％,79.17％,82.46％,38.78％and 96.58％,respectively;which in the TCT ex-amination results were 92.82％,70.83％,95.91％,70.83％and 95.91％,respectively;which in the joint ex-aminations were 97.95％,91.67％,98.83％,91.67％and 98.83％,respectively;the diagnostic accuracy,sensi-tivity,specificity,positive predictive value and negative predictive value of joint examination were higher than those of HPV-DNA and TCT single examination;the receiver operating characteristic(ROC)curve showed that the area under the curve(AUC)of TCT combined with HPV-DNA detection was 0.815(95％CI:0.722-0.931).Conclusion The combination detection of TCT and HPV-DNA has a high screening value for cervical cancer,which could improve the detection rate of cervical cancer.
