Impact of ondansetron on risk of delirium occurrence in ICU patients
10.3969/j.issn.1671-8348.2025.09.018
- VernacularTitle:昂丹司琼对ICU患者谵妄发生风险的影响
- Author:
Rui ZHAO
1
;
Liming CHENG
;
Yujun WEI
;
Jian HUO
;
Anmin HU
;
Weitao CHEN
Author Information
1. 昆明市儿童医院麻醉科,昆明 650034
- Keywords:
ondansetron;
delirium;
critical illness;
big data;
propensity score matching
- From:
Chongqing Medicine
2025;54(9):2103-2106,2111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of ondansetron's use within 24 h before delirium assess-ment in ICU patients on the risk of delirium occurrence.Methods All data were derived from the Critical Care Medical Information Database(MIMIC)-Ⅲ,MIMIC-Ⅳ and the eICU Collaborative Research Database.The research subjects were the patients who were admitted to ICU for treatment for the first time and had re-cords of delirium assessment.The research variable was whether ondansetron was used within 24 h before de-lirium assessment.The main observation indicator was whether delirium occurred after the patient entering to ICU,and whether the patient died during hospitalization or was discharged and returned home was taken as the secondary observation indicator.The propensity score matching eliminated confounding factors,and the stepwise logistic regression and nearest neighbor matching were used to analyze the influencing factors.Results A total of 78 364 patients had the delirium assessment records,among them 22 158 patients had the positive assessment results.A total of 294 patients who used ondansetron within 24 h before delirium assess-ment were taken as the ondansetron group,and 78 070 patients who did not use ondansetron were taken as the control group.Propensity score matching corrected most of the covariates between the two groups.The results of multivariate logistic regression analysis showed that the use of ondansetron was a protective factor for the delirium occurrence(OR=0.72,95％CI:0.53-0.96),and the results of nearest neighbor matching analysis also supported this association(OR=0.48,95％CI:0.31-0.76).However,the use of ondansetron had no effect on the outcome of in-hospital death or discharge home for critically ill patients(P＞0.05).Conclusion Ondansetron may be an effective drug for the prevention or treatment of delirium in critically ill patients.
