Clinical efficacy of Qizhi Mixture combined with telmisartan tablets in treatment of qi deficiency and blood stasis type IgA nephropathy and its influence on liver and kidney functions
10.3969/j.issn.1671-8348.2025.09.004
- VernacularTitle:芪蛭合剂联合替米沙坦片对气虚血瘀型IgA肾病临床疗效的影响
- Author:
Huahong ZHOU
1
;
Yi DONG
;
Xiaojun FU
Author Information
1. 浙江中医药大学附属金华中医院,浙江金华 321017
- Keywords:
IgA nephropathy;
Qizhi Mixture;
telmisartan tablets;
qi deficiency and blood stasis;
clinical efficacy
- From:
Chongqing Medicine
2025;54(9):2018-2022,2027
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of Qizhi Mixture combined with telmisartan tab-lets in the treatment of qi deficiency and blood stasis type IgA nephropathy.Methods A total of 98 patients with qi deficiency and blood stasis type IgA nephropathy admitted and treated in this hospital from January 2020 to December 2023 were selected and divided into the experimental group and control group according to the envelope method.The control group adopted telmisartan tablets,and the experimental group adopted Qizhi Mixture combined with telmisartan tablets.The clinical efficacies were compared between the two groups,as well as the renal function,liver function,vessel endothelial cell function and oxidative stress response indica-tors in the two groups.The occurrence of adverse reactions in the two groups were observed.Results The to-tal treatment effective rate in the experimental group was significantly higher than that in the control group(95.92％vs.79.59％).After treatment,the levels of SCr,BUN and NGAL in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The ALB level after treatment in the experimental group was higher than that in the control group,the ALT and TBIL levels were lower than that in the control group,and the difference was statistically significant(P＜0.05).The levels of VEGF and ET-1 after treatment in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of GSH-Px and SOD after treat-ment in the experimental group were higher than those in the control group,the level of MDA was lower than that in the control group,and the differences were statistically significant(P＜0.05).The incidence rate of ad-verse reactions in the experimental group was lower than that in the control group,and the difference was sta-tistically significant(6.12％vs.22.45％,P＜0.05).Conclusion Qizhi Mixture combined with telmisartan tablets in the treatment of qi deficiency and blood stasis type IgA nephropathy could improve the liver and re-nal function and endothelial cell function of the patients,reduce the oxidative stress responses and decrease the adverse reactions.
