PK-PD study on anti-post-stroke depression effect of Xuesaitong Soft Capsules
10.3969/j.issn.1671-8348.2025.09.002
- VernacularTitle:血塞通软胶囊抗卒中后抑郁的PK-PD研究
- Author:
Juan YANG
1
;
Hui LI
;
Rui LU
;
Yangyang YU
;
Ruoxi FAN
;
Yanshuang LIU
;
Yidan LIU
;
Junfeng LIU
;
Ningna ZHOU
Author Information
1. 云南中医药大学中药学院暨云南省南药可持续利用研究重点实验室,昆明 650500
- Keywords:
post-stroke depression;
Xuesaitong Soft Capsule;
norepinephrine;
5-hydroxytryptamine;
ginsenoside Re;
PK-PD model
- From:
Chongqing Medicine
2025;54(9):2007-2013
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily explore the potential efficacy of Xuesaitong Soft Capsule(XST)against post-stroke depression(PSD),and to investigate the material basis of XST's anti-PSD effect based on the metabolomics results to analyze its related pharmacokinetic(PK)characteristics and further analyze the pharmacodynamic(PD)equation of representative ingredients.Methods The initial evaluation of drug effica-cy was conducted by detecting the depressive-like behavior and neurotransmitter levels in rats.The Pearson correlation analysis was employed to analyze the correlation between the main metabolites regulated by XST and the saponin components entering the bloodstream.At various time points after drug administration,the blood concentration of ginsenoside Re and the concentration of norepinephrine(NE)in the serum of PSD rats were measured,and the compartment model was fitted accordingly.Furthermore,the liquid chromatography-mass spectrometry was utilized to determine the content of ginsenoside Re in the liver,spleen,kidney,prefron-tal cortex,hippocampus and striatum of PSD rats.Results Ginsenoside Re showed the optimal correlation by the Pearson correlation analysis.Based on its pharmacokinetic parameters,the pharmacodynamic equation with NE was E=160.462 × Ce/(38.663+Ce).The contents of ginsenoside Re in the liver,spleen,kidney,prefron-tal cortex,hippocampus and striatum of rats were(17.23+11.90),(19.05+5.67),(1.95+0.79),(70.13+6.75),(57.03+3.11),and(72.45+5.45)ng/g,respectively.Conclusion XST could improve the depressive-like behaviors in PSD rats by regulating the expression levels of neurotransmitter NE and 5-HT.Ginsenoside Re may be the pharmacodynamical material foundation for XST's preventative treatment of PSD.
