Research progress on the effect of fat emulsions on the in vitro membrane lung oxygenation system

VernacularTitle:脂肪乳剂对体外膜肺氧合系统影响的研究进展
Author: Liwen YANG ¹ ; Bin XIONG ; Jing PANG ; Shulin XIANG
Author Information

1. 广西医学科学院/广西壮族自治区人民医院重症医学科,南宁 530000
Keywords: intravenous lipid emulsion; extracorporeal membrane oxygenation; propofol; ciprofol; effect
From: Chongqing Medicine 2025;54(8):1940-1944,1951
CountryChina
Language:Chinese
Abstract: According to statistics from the Extracorporeal Life Support Organization(ELSO),as of October 2023,a total of 198 623 patients worldwide had received extracorporeal membrane oxygenation(EC-MO)support.In recent years,the number of ECMO treatment cases in China has increased rapidly,reaching 10 656 cases in 2022.It was previously believed that fat emulsions could easily lead to ECMO system failures due to their hydrophobic nature,thereby limiting their use during ECMO.However,many clinically used drugs are lipid-soluble,and restricting their use not only increases treatment difficulty for these patients but may e-ven affect their prognosis.With advancements in material technology and membrane lung manufacturing processes,intravenous lipid emulsion(ILE)now exerts significant effects on ECMO systems.This article re-views recent domestic and international research progress regarding the effects of ILE on ECMO systems,ai-ming to provide more evidence-based medical support for ILE application in ECMO patients.