The role of immune cells in the occurrence and development of liver fibrosis
10.3969/j.issn.1671-8348.2025.08.030
- VernacularTitle:免疫细胞在肝纤维化发生与发展中的作用
- Author:
Wenjuan MA
1
;
Xuguo YANG
;
Zhenyu TIE
;
Yongmao ZHANG
;
Zhenxiang WANG
Author Information
1. 河西学院医学院,甘肃 张掖 734000
- Keywords:
hepatic fibrosis;
extracellular matrix;
immune cells;
targeted therapy
- From:
Chongqing Medicine
2025;54(8):1936-1939
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis(HF)is an inevitable process for many chronic liver diseases to develop into liver cirrhosis and even liver cancer.More than 80%of hepatocellular carcinomas are formed after the process of chronic hepatitis,HF or liver cirrhosis.The immune microenvironment produced by inflammation and fi-brosis plays a significant role in promoting the occurrence and development of hepatocellular carcinoma.He-patic stellate cells(HSC),extracellular matrix(ECM),and fibroblasts are involved in the progression of HF by influencing innate immunity and adaptive immunity.This article,by analyzing the role of immune cells in HF,is expected to provide new intervention approaches and therapeutic targets for the clinical treatment of HF,thereby further enhancing the effectiveness of immunotherapy and offering safer and more effective treat-ment options for HF patients.
