Analysis of influencing factors and prognosis of failed initial invasive mechanical ventilation weaning in extremely premature infants
10.3969/j.issn.1671-8348.2025.08.027
- VernacularTitle:超早产儿初次有创机械通气撤机失败的影响因素及预后分析
- Author:
Na SU
1
;
Xiangwen HU
;
Wenjun ZHOU
;
Kaizhen LIU
;
Wenyan TANG
Author Information
1. 江西省妇幼保健院新生儿科,南昌 330000
- Keywords:
extremely preterm infants;
invasive mechanical ventilation;
weaning;
influencing factor;
prognosis
- From:
Chongqing Medicine
2025;54(8):1918-1923
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influencing factors and prognosis of failed initial invasive mechani-cal ventilation weaning in extremely premature infants.Methods A retrospective analysis was conducted on the clinical data of 143 extremely premature infants who were delivered at Jiangxi Maternal and Child Health Hospital and treated in the neonatal intensive care unit(NICU)from July 2021 to June 2024 and received in-vasive mechanical ventilation within 72 hours after birth.According to whether re-intubation was required within 72 hours after the initial weaning,they were divided into the successful weaning group(n=110)and the failed weaning group(n=33).Stepwise logistic regression was used to analyze the influencing factors and prognosis of failed initial invasive mechanical ventilation weaning.Results There were statistically significant differences between the two groups with different gestational ages at birth,birth weights,tracheal intubation in the delivery room or operating room,abnormal C reactive protein at admission,fraction of inspiration O2(FiO2)at admission,gestational age before weaning from the ventilator,weight before weaning from the vent-ilator,patent ductus arteriosus(PDA,≥2.5 mm),proportion of≥3 tracheal intubation times,invasive me-chanical ventilation time,oxygen supply time,and hospitalization expenses(P<0.05).The results of multiva-riate logistic regression analysis showed that gestational age at birth,abnormal C reactive protein at admis-sion,FiO2 at admission,gestational age before weaning from the ventilator,PDA(≥2.5 mm),duration of in-vasive mechanical ventilation,pulmonary hemorrhage,feeding intolerance,time to total enteral feeding,shock,and length of hospital stay were independent influencing factors for failed initial invasive mechanical ventila-tion weaning(P<0.05).Conclusion Early prevention and early treatment of risk factors are the keys to the successful weaning of extremely premature infants.
