Analysis of the value of sFlt-1/PlGF in predicting vitamin D deficiency in pregnant women with preeclampsia
10.3969/j.issn.1671-8348.2025.08.022
- VernacularTitle:sFlt-1/PlGF预测子痫前期孕妇发生维生素D缺乏的价值分析
- Author:
Xiaoduo LI
1
;
Yan ZHANG
;
Yuanyu ZHANG
;
Xia CHEN
;
Li JIANG
;
Wei LIN
;
Xiaojing DONG
Author Information
1. 重庆市綦江区妇幼保健院妇产科,重庆 401420
- Keywords:
preeclampsia;
vitamin D;
soluble fms-like tyrosine kinase-1;
placental growth factor;
predic-tive value
- From:
Chongqing Medicine
2025;54(8):1888-1893
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of the ratio of soluble FmS-like tyrosine kinase-1(sFlt-1)to placental growth factor(PlGF)in predicting vitamin D deficiency in pregnant women with preeclampsia.Methods A total of 740 singleton pregnant women who underwent prenatal examination in Qijiang Health Center for Maternal and Child Care from January to November 2023 and were able to complete follow-up were selected as the research subjects.They were divided into the normal group(n=44)and the deficiency group(n=696)according to the vitamin D[1,25-(OH)2D3]level.Information such as age,BMI,pregnancy histo-ry,family history and medical history of each group was collected.5 mL of peripheral venous blood was drawn after fasting for 6-8 hours at 12-14 weeks of pregnancy to detect the levels of sFlt-1,PlGF and vitamin D in peripheral blood,and evaluated the predictive value of sFlt-1/PlGF for vitamin D deficiency in preeclampsia.Results There were no statistically significant differences in general conditions such as height,age,BMI,edu-cational level and occupation between the two groups(P>0.05).There were statistically significant differ-ences in the prenatal weight,vitamin D level,sFlt-1/PlGF and neonatal birth weight between the two groups(P<0.05).The results of univariate analysis showed that the prenatal weight,sFlt-1/PlGF,and neonatal birth weight were risk factors for vitamin D deficiency in patients with PE.The results of multivariate analysis showed that sFlt-1/PlGF and neonatal birth weight were factors for predicting vitamin D deficiency in patients with PE(P<0.05).All these variables are used to establish the nomogram prediction model.The receiver op-erating characteristic(ROC)curve showed that area under the curve(AUC)of the training group and the val-idation group was 0.66(95%CI:0.56-0.77)and 0.63(95%CI:0.49-0.76),respectively.Conclusion In pregnant women with preeclampsia,elevated sFlt-1/PlGF may be an early warning indicator for predicting vi-tamin D deficiency.
