Short-term longitudinal study on the effect of expression states of δ-catenin on the brain small-world network in breast cancer patients before and after chemotherapy
10.3969/j.issn.1671-8348.2025.08.014
- VernacularTitle:δ-连环蛋白表达状态对乳腺癌患者化疗前后脑小世界网络影响的短期纵向研究
- Author:
Rongrong YAO
1
;
Mingtuan XUE
Author Information
1. 锦州医科大学赤峰学院培养基地,辽宁 锦州 121000;内蒙古阿荣旗人民医院功能科,内蒙古 呼伦贝尔 162750
- Keywords:
breast cancer;
brain small-world network;
δ-catenin;
magnetic resonance imaging
- From:
Chongqing Medicine
2025;54(8):1841-1847
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of different δ-catenin expression levels on brain small-world network alterations before and after chemotherapy in breast cancer patients using resting-state function-al MRI(rs-fMRI).Methods A total of 66 breast cancer patients who were pathologically diagnosed and did not receive the first chemotherapy were included and divided into the high-expression(DH)group(n=31)and the low-expression(DL)group(n=35)according to the expression level of δ-catenin.rs-fMRI were per-formed before and after chemotherapy respectively to calculate the attributes of the brain small-world net-work,including parameters such as node local efficiency(NE),betweenness centrality(BC),degree centrality(DC)and the changes in the attributes of the brain small-world network of patients before and after chemo-therapy were analyzed.Results There was no statistically significant difference in the longitudinal comparison of network indicators such as small-world coefficient(σ),characteristic path length(λ),cluster coefficient(γ),local clustering coefficient(Cp),average shortest path length(Lp),global efficiency(Eg),and local effi-ciency(Eloc)before and after chemotherapy between the DL group and the DH group(P>0.05).In the DL group,post-chemotherapy NE values was decreased in the left olfactory cortex,bilateral orbital superior fron-tal gyri,right gyrus rectus,and left caudate nucleus,while increased in the bilateral central operculum,left su-perior parietal gyrus,right superior temporal gyrus,and temporal pole of the right superior temporal gyrus.In the DH group,post-chemotherapy NE values was decreased in the bilateral supplementary motor area and right angular gyrus,and right superior temporal gyrus,but increased in the left globus pallidus.Post-chemo-therapy BC values in the DL group was decreased in the left pericalcarine cortex,right lingual gyrus,and left caudate nucleus,and increased in the left medial superior frontal gyrus.In the DH group,post-chemotherapy BC values was decreased in the right supplementary motor area and right caudate nucleus,while increased in the right posterior cingulate gyrus and left globus pallidus.Post-chemotherapy DC values in the DL group was decreased in the left supplementary motor area,right gyrus rectus,and left caudate nucleus,but increased in the right opercular part of the inferior frontal gyrus,right central operculum,right temporal pole of the superi-or temporal gyrus,right superior temporal gyrus,left superior parietal gyrus,left angular gyrus,and bilateral supramarginal gyri.In the DH group,post-chemotherapy DC values was decreased in the left precentral gyrus,bilateral supplementary motor areas,left fusiform gyrus,right angular gyrus,and right superior temporal gy-rus,while increased in the left globus pallidus.Conclusion The high expression of δ-catenin may further ag-gravate the damage of chemotherapy to the brain small-world network of breast cancer patients,mainly invol-ving motor and cognition-related brain regions.
