Study on the preventive effect of ipratropium bromide on sufentanil-induced cough during general anesthesia induction
10.3969/j.issn.1671-8348.2025.08.009
- VernacularTitle:异丙托溴铵对全身麻醉诱导期舒芬太尼诱发呛咳的预防效果研究
- Author:
Gaojie LI
1
;
Shujun XU
;
Tiantian HAN
;
Zhen ZHANG
Author Information
1. 湖北医药学院附属襄阳市第一人民医院麻醉科,湖北 襄阳 441100
- Keywords:
ipratropium bromide;
sufentanil;
opioid analgesics;
cough;
general anesthesia
- From:
Chongqing Medicine
2025;54(8):1816-1819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effect of ipratropium bromide on sufentanil-induced cough during general anesthesia induction.Methods A total of 201 patients undergoing elective surgery under general anesthesia from June 2022 to September 2024 were selected and divided into the ipratropium bromide group(group P,n=100)and the normal saline group(group C,n=101).Thirty minutes before anesthesia in-duction,group P and group C received oral administration of ipratropium bromide inhalation aerosol(2 puffs,equivalent to 42 μg C20H30BrNO3·H2O)and 0.9%normal saline spray(2 puffs),respectively.Anesthesiolo-gists intravenously administered sufentanil(0.5 μg/kg)within 5 seconds,followed by propofol(2 mg/kg)and rocuronium(0.6 mg/kg)after 3 minutes.Endotracheal intubation was performed using a videolaryngo-scope after achieving satisfactory muscle relaxation.The occurrence of cough within 1 minute after sufentanil administration was recorded.Heart rate(HR),mean arterial pressure(MAP),and pulse oxygen saturation(SpO2)were measured at different time points.Results Within 1 min after sufentanil administration,the in-cidence of severe cough and total cough in group P was significantly lower than that in group C(P<0.05).There was no significant difference in HR,MAP,or SpO2 between the two groups at different times(P>0.05).No adverse reactions such as nausea,vomiting,or arrhythmia occurred in either group.Conclusion In-haling ipratropium bromide 30 min before anesthesia induction could effectively reduce sufentanil-induced cough and decrease the incidence of severe cough.
