Association analysis of childhood obesity and inflammatory bowel disease based on Mendel randomization
10.3969/j.issn.1671-8348.2025.08.006
- VernacularTitle:基于孟德尔随机化的儿童肥胖与炎症性肠病的关联分析
- Author:
Wenhua FENG
1
;
Fang GOU
;
Yi ZHANG
;
Rui LIANG
;
Lei PENG
;
Shaohua ZHANG
Author Information
1. 四川大学华西医院绵竹医院/绵竹市人民医院儿科,四川 德阳 618200
- Keywords:
child;
obesity;
inflammatory bowel disease;
ulcerative colitis;
Crohn's disease;
Mendelian randomization study;
causal relationship
- From:
Chongqing Medicine
2025;54(8):1798-1803
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential causal relationship between childhood obesity and the risk of inflammatory bowel disease(IBD)based on Mendel randomization(MR).Methods The genome-wide association study(GWAS)data for childhood obesity included 5 530 cases and 8 318 controls.The GWAS data for IBD included 5 673 cases and 213 119 controls.The GWAS data for ulcerative colitis included 4 320 cases and 210 300 controls.The GWAS data of Crohn's disease included 2 056 cases and 210 300 controls.The risk association between obesity and the occurrence of IBD was analyzed using the inverse variance weighted meth-od(IVW),general model,weighted model,weighted median,and MR-Egger.Results Fourteen independent single nucleotide polymorphisms(SNP)significantly associated with childhood obesity were screened out as instrumental variables.IVW analysis results showed that no potential causal association was found between childhood obesity and IBD(OR=1.048,95%CI:0.976-1.125),ulcerative colitis(OR=1.026,95%CI:0.946-1.113),and Crohn's disease(OR=1.123,95%CI:0.993-1.269,P>0.05).Conclusion There was no causal relationship between childhood obesity and the risk of IBD.
