Research progress on the PI3K/Akt pathway in cerebral ischemia-reperfusion injury

VernacularTitle:PI3K/Akt通路在脑缺血再灌注损伤中的研究进展
Author: Jiahua SHI ¹ ; Kaihua WANG ; Zhenzhen CHEN ; Longjian HUANG
Author Information

1. 广西中医药大学,南宁 530200
Keywords: PI3K/Akt; signaling pathway; cerebral ischemia-reperfusion injury; ischemic stroke
From: Chongqing Medicine 2025;54(7):1729-1733
CountryChina
Language:Chinese
Abstract: Cerebral ischemia-reperfusion injury(CIRI)is an important component of ischemic stroke,specifically referring to the phenomenon where reperfusion exacerbates tissue damage after the restoration of blood flow.The underlying mechanisms involve factors such as free radical damage,calcium overload,and in-flammatory damage.Currently,there are no particularly effective treatments for this injury clinically.Phos-phatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling is a classical cellular pathway that regulates downstream substrates through Akt phosphorylation to regulate cell growth,differentiation,and apoptosis.Studies have shown that PI3K/Akt is involved in regulating multiple forms of programmed cell death inclu-ding apoptosis within the organism,and this pathway plays a role in antioxidant stress and anti-inflammatory responses during the process of combating CIRI.This review summarizes recent advances of PI3K/Akt path-way in CIRI regulation,this paper provides new ideas and reference for basic and clinical research.