Research progress on the application of CAR-T combination therapy in solid tumors
10.3969/j.issn.1671-8348.2025.07.033
- VernacularTitle:CAR-T疗法联合治疗在实体肿瘤中的应用研究进展
- Author:
Jinli GAO
1
;
Xinpei CAI
;
Qinqin XU
Author Information
1. 青海大学研究生院,西宁 810000
- Keywords:
chimeric antigen receptor T-cell;
radiofrequency ablation;
immunosuppressants;
oncolytic virus;
tumor
- From:
Chongqing Medicine
2025;54(7):1719-1723,1728
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor T-cell(CAR-T)immunotherapy utilizes genetic engineering to modify human T cells,enabling them to specifically recognize antigens on tumor cell surfaces through antibod-ies and to link with signaling molecules necessary for T-cell activation,thereby enhancing the T cells'specific cytotoxic activity against tumors.Currently,it demonstrates significant efficacy in the treatment of hematolog-ical tumors;however,numerous challenges remain in treating solid tumors,as its effectiveness is influenced by drug resistance of antigen-negative tumor cells,immune suppression in the tumor microenvironment,and ex-haustion of T cell immune function.This article provides a review of the application of current combination therapies utilizing CAR-T cell therapy,aiming to offer novel approaches for the treatment of solid tumors.
