Clinical analysis of 16 cases of mucosal malignant melanoma in the nasal and paranasal sinuses without cervical lymph node metastasis

VernacularTitle:16例无颈淋巴结转移的鼻腔鼻窦黏膜恶性黑色素瘤的临床分析
Author: Huixi WANG ¹ ; Xiaohua LUO ; Xiang CHEN ; Yiling WANG
Author Information

1. 重庆大学附属涪陵医院耳鼻咽喉头颈外科,重庆 408000
Keywords: nasal and paranasal sinuses; melanoma; bone destruction; endoscopic sinus surgery; immu-notherapy
From: Chongqing Medicine 2025;54(7):1661-1666
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical features,diagnosis,treatment and prognosis of sinon-asal mucosal melanoma(SNMM).Methods The clinical data of 16 cases of SNMM without cervical lymph node metastasis admitted to this hospital from June 2014 to July 2021 were retrospectively analyzed.Results The mean age of all 16 cases was(70.00±7.02)years.The mean survival period was 22.87 months in the treated group and 9.42 months in the untreated group,with significant difference in outcome(P=0.01).There was no significant difference in long-term prognosis between patients with bone destruction and those without bone destruction after treatment(P=0.085).There was also no significant difference in prognosis between T3 group and T4a group after treatment(P=0.119).Conclusion SNMM usually presents with mi-nor nasal bleeding as the initial symptom,and the overall prognosis is poor due to its propensity for metasta-sis.Surgical resection and postoperative individualized comprehensive therapy are the main treatments,and immunotherapy may improve survival.