Study on the effect of cytokines on pulmonary arterial hypertension based on Mendelian randomization
10.3969/j.issn.1671-8348.2025.07.019
- VernacularTitle:基于孟德尔随机化的细胞因子对肺动脉高压的影响研究
- Author:
Genghua HE
1
;
Jiankang YANG
Author Information
1. 大理大学基础医学院,云南 大理 671000
- Keywords:
pulmonary arterial hypertension;
interleukin-9;
β-nerve growth factor;
genome-wide associ-ation study;
Mendelian randomization
- From:
Chongqing Medicine
2025;54(7):1637-1641,1647
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the impact of cytokines on pulmonary arterial hypertension using a bi-directional Mendelian randomization(MR)approach.Methods The data for 41 cytokines were derived from a genome-wide association study(GWAS)dataset consisting of 8,293 individuals of European descent,and the genetic data for pulmonary arterial hypertension were obtained from a GWAS dataset comprising 11,744 indi-viduals of European descent;the potential impact of cytokines on pulmonary arterial hypertension was ex-plored using MR analysis.Results The inverse variance weighted(IVW)analysis revealed a potential causal relationship between IL-9 and pulmonary arterial hypertension(OR=0.63,95%CI:0.50 to 0.78,P<0.001),and a potential causal relationship between β-NGF and pulmonary arterial hypertension(OR=1.34,95%CI:1.01 to 1.79,P=0.049).Multivariable MR analysis demonstrated an association between IL-9 and pulmonary arterial hypertension(OR=0.57,95%CI:0.44 to 0.72,P<0.001),as well as between β-NGF and pulmonary arterial hypertension(OR=1.47,95%CI:1.10 to 1.97,P=0.009).Conclusion Elevated IL-9 levels may be causally associated with a reduced risk of pulmonary arterial hypertension,while increased β-NGF levels may elevate the risk of pulmonary arterial hypertension.
