Role of HOX genes in lung cancer and their significance for early diagnosis
10.3969/j.issn.1671-8348.2025.06.030
- VernacularTitle:HOX基因在肺癌中的作用及早期诊断意义
- Author:
Lingxiang ZHANG
1
;
Zhong XU
;
Shu WU
;
Lin YE
Author Information
1. 重庆医科大学附属第一医院胸心外科,重庆 400016
- Keywords:
lung cancer;
homeobox genes;
early diagnosis
- From:
Chongqing Medicine
2025;54(6):1453-1458
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer remains the disease with the highest incidence and mortality rates globally,po-sing a severe threat to human health.HOX genes constitute an evolutionarily conserved family of transcription factors that play critical roles in embryonic development,tissue patterning,and cell differentiation.Dysregula-tion of HOX gene expression has been observed in many malignant tumors,affecting tumorigenesis,progres-sion,and treatment response.This article reviewed systematically summarized the expression,functions,and diagnostic significance of HOX genes in lung cancer.
