Research progress of NLRP3 inflammasome in the treatment of leukemia
10.3969/j.issn.1671-8348.2025.06.029
- VernacularTitle:NLRP3炎症小体在白血病中的研究进展
- Author:
Haiyan SUN
1
;
Shiyan ZHOU
;
Shanshan ZHANG
;
Qian ZHANG
Author Information
1. 中国人民解放军联勤保障部队第九四〇医院血液科,兰州 730050;甘肃中医药大学第一临床医学院,兰州 730030
- Keywords:
nucleotide binding oligomerization domain like receptor protein 3 inflammasome;
activation pathway;
leukemia;
myelodysplastic syndrome;
pyrodeath
- From:
Chongqing Medicine
2025;54(6):1447-1452,1458
- CountryChina
- Language:Chinese
-
Abstract:
The nucleotide binding oligomerization domain like receptor protein 3(NLRP3)inflamma-some is an intracellular polymeric protein complex that plays an important role in inflammation and immune response.In recent years,the study of NLRP3 inflammasome in hematological malignancies has become a hot topic.Leukemia is a large group of clonal hematologic malignancies that affect the maturation and/or prolifer-ation of bone marrow or lymphocytes.More and more studies have shown that NLRP3 inflammatory micro-molecules are involved in the occurrence and development of leukemia,and it is expected to become an impor-tant therapeutic target for leukemia in the future.In this review,the structure,biological function,activation pathway of NLRP3 inflammasome and its relationship with different types of leukemia were reviewed,and its potential application in the treatment of leukemia was discussed.
