Mendelian randomization study on the causal relationship between obstructive sleep apnea and dementia
10.3969/j.issn.1671-8348.2025.06.019
- VernacularTitle:阻塞性睡眠呼吸暂停与痴呆因果关系的孟德尔随机化研究
- Author:
Haiwen HUANG
1
;
Yonglin LI
;
Haisheng CHEN
;
Min GAO
Author Information
1. 广州中医药大学第五临床医学院,广州 410000
- Keywords:
obstructive sleep apnea;
dementia;
vascular dementia;
Mendelian randomization
- From:
Chongqing Medicine
2025;54(6):1382-1388,1393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between obstructive sleep apnea(OSA)and common types of dementia by using Mendelian randomization(MR)analysis methods.Methods Based on summary data from large-scale genome-wide association studies(GWAS),single nucleotide polymorphisms(SNP)highly associated with OSA,Alzheimer's disease(AD),vascular dementia(VaD),dementia with Lewy bodies(DLB),and frontotemporal dementia(FTD)were selected as instrumental variables.The inverse variance weighted method(IVW)was employed as the primary analytical method,and stability tests were conducted by using the simple median method,weighted median method(WME),MR-Egger regression meth-od,simple mode(SM)and weighted mode(WM).Additionally,F-statistics,Cochran'Q test,MR-Egger re-gression intercept test,and leave-one-out method were used for weak instrument variables bias testing,hetero-geneity testing,pleiotropy analysis,and sensitivity analysis,respectively.Causal associations were evaluated by using odds ratios(OR)and 95%CI.Results MR analysis showed that OSA was associated with an increased risk of VaD(OR=1.829,95%CI:1.024-3.266,P<0.05).All F-statistics were>10,indicating no weak in-strumental variables.Cochran'Q test and MR-Egger regression intercept test revealed no heterogeneity and horizontal pleiotropy(P>0.05).Conclusion Genetic-level prediction suggests that OSA is associated with an increased risk of VaD.Early prevention and treatment of OSA may help improve patients'quality of life.
