Clinical study on the therapeutic effect of Guanxinning tablets in the treatment of diastolic heart failure
10.3969/j.issn.1671-8348.2025.06.015
- VernacularTitle:冠心宁片治疗舒张性心力衰竭的临床效果研究
- Author:
Jiamei WU
1
;
Qingbin ZHOU
Author Information
1. 浙江省桐乡市中医医院药剂科,浙江 嘉兴 314500
- Keywords:
diastolic heart failure;
traditional Chinese medicine;
inflammation;
Guanxinning tablets;
car-diac function;
blood routine
- From:
Chongqing Medicine
2025;54(6):1361-1365,1371
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Guanxinning tablets in the treatment of di-astolic heart failure(DHF).Methods A total of 98 patients with DHF admitted to our hospital from Decem-ber 2021 to December 2022 were selected as study subjects and randomly divided into a control group and an observation group,with 49 cases in each group.The control group received oral medication according to the es-tablished protocol,while the observation group additionally received Guanxinning tablets orally on the basis of the control group's treatment.Both groups underwent a 4-week treatment period.Clinical efficacy,cardiac function indicators,blood routine parameters,cardiovascular and inflammatory markers,and left ventricular diastolic function indicators were compared between the two groups before and after treatment.Results After treatment,the total effective rate in the observation group(97.96%)was higher than that in the control group(85.71%),with statistically significant differences(P<0.05).The observation group exhibited higher left ventricular ejection fraction(LVEF)and lower left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)compared to the control group,with statistically significant differ-ences(P<0.05).All blood routine parameters and cardiovascular/inflammatory markers in the observation group were significantly lower than those in the control group(P<0.05).Additionally,the observation group showed higher E-peak and E/A ratio,along with lower A-peak and E-peak deceleration time(DT),compared to the control group,with statistically significant differences(P<0.05).Conclusion Guanxinning tablets can stabilize blood routine levels,inhibit vascular inflammation,improve cardiac function and left ventricular dias-tolic function,and alleviate heart failure symptoms in DHF patients.
