Analysis of serum ANGPTL4 and FGF-21 levels in patients with acute cerebral infarction complicated with type 2 diabetes and their relationship with disease condition and carotid plaque stability
10.3969/j.issn.1671-8348.2025.06.009
- VernacularTitle:急性脑梗死合并2型糖尿病患者血清ANGPTL4、FGF-21水平及其与病情、颈动脉斑块稳定性的关系分析
- Author:
Junjie ZHANG
1
;
Weiping ZHOU
Author Information
1. 三峡大学附属第二人民医院·宜昌市第二人民医院神经内科(睡眠医学中心),湖北 宜昌 443000
- Keywords:
acute cerebral infarction;
type 2 diabetes;
angiopoietin-like protein 4;
fibroblast growth fac-tor-21;
disease condition;
carotid plaque;
plaque stability
- From:
Chongqing Medicine
2025;54(6):1329-1333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the serum levels of angiopoietin-like protein 4(ANGPTL4)and fibro-blast growth factor-21(FGF-21)in patients with acute cerebral infarction complicated with type 2 diabetes,and explore their relationships with disease condition and carotid plaque stability.Methods A total of 224 pa-tients with acute cerebral infarction complicated with type 2 diabetes admitted to this hospital from June 2019 to June 2022 were selected as the study group,and 224 healthy volunteers undergoing physical examinations in the hospital during the same period were selected as the control group.Serum ANGPTL4 and FGF-21 levels were detected by ELISA.The National Institutes of Health Stroke Scale(NIHSS)was used to evaluate the severity of the disease.Patients were divided into the mild group(n=84,NIHSS score<4 points),the moder-ate group(n=100,NIHSS score 4-15 points),and the severe group(n=40,NIHSS score>15 points).Ca-rotid plaque stability was assessed by color Doppler ultrasound,and patients were divided into the no-plaque group(n=44),the stable plaque group(n=71),and the unstable plaque group(n=109).Pearson correlation analysis was used to analyze the correlation between serum ANGPTL4 level and FGF-21 level.Spearman cor-relation analysis was used to analyze the correlations between serum ANGPTL4/FGF-21 levels and disease se-verity or carotid plaque stability.Logistic regression analysis was performed to analyze the influencing factors of acute cerebral infarction complicated with type 2 diabetes.Results The serum ANGPTL4 level in the study group was significantly lower than that in the control group(P<0.05),while the FGF-21 level was signifi-cantly higher(P<0.05).Serum ANGPTL4 levels decreased progressively in the mild,moderate,and severe groups(P<0.05),while FGF-21 levels increased progressively(P<0.05).Serum ANGPTL4 levels also de-creased progressively in the no-plaque,stable plaque,and unstable plaque groups(P<0.05),while FGF-21 levels increased progressively(P<0.05).Pearson correlation analysis showed a negative correlation between serum ANGPTL4 and FGF-21 levels(r=-0.576,P<0.05).Spearman correlation analysis showed that ser-um ANGPTL4 level were negatively correlated with disease severity and carotid plaque stability(r=-0.561,-0.529;P<0.05),while serum FGF-21 levels were positively correlated with disease severity and carotid plaque stability(r=0.592,0.610;P<0.05).Logistic regression analysis showed that low ANGPTL4 expres-sion and high FGF-21 expression were risk factors for acute cerebral infarction complicated with type 2 diabe-tes(P<0.05).Conclusion In patients with acute cerebral infarction complicated with type 2 diabetes,serum ANGPTL4 level is significantly decreased,while FGF-21 is significantly increased compared with healthy indi-viduals.Both factors are closely associated with disease severity and carotid plaque stability.
