Correlation analysis of WT1,BCR-ABL genes with IL-6,VEGF,PC and PS in myeloproliferative neoplasms
10.3969/j.issn.1671-8348.2025.06.007
- VernacularTitle:骨髓增殖性肿瘤WT1、BCR-ABL基因与IL-6、VEGF、PC、PS的相关性分析
- Author:
Jianwei DENG
1
;
Qingren LUO
;
Huiwen ZHU
;
Yuping LIN
Author Information
1. 江门市五邑中医院检验科,广东 江门 529000
- Keywords:
myeloproliferative tumor;
WT1;
BCR-ABL;
interleukin-6;
vascular endothelial growth fac-tor;
plasma protein C;
plasma protein S;
correlation
- From:
Chongqing Medicine
2025;54(6):1319-1322,1328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between WT1,BCR-ABL genes and interleukin-6(IL-6),vascular endothelial growth factor(VEGF),plasma protein C(PC),plasma protein S(PS)in patients with myeloproliferative neoplasms(MPN).Methods A total of 54 MPN patients treated in this hospital from January 2021 to January 2024 were selected as the MPN group,and 54 healthy subjects undergoing physical examination during the same period were selected as the control group.The gene relative expression levels of WT1,BCR-ABL and levels of IL-6,VEGF,PC,and PS were detected and compared between the two groups.The correlations between WT1,BCR-ABL gene relative expression levels and IL-6,VEGF,PC,PS levels were analyzed,and the diagnostic efficacy of WT1 and BCR-ABL genes for MPN was evaluated by receiver operat-ing characteristic(ROC)curve.Results Compared with the control group,the gene relative expression levels of WT1,BCR-ABL and the levels of IL-6 and VEGF in the MPN group were higher,while the levels of PC and PS were lower,with statistically significant differences(P<0.05).Pearson correlation analysis showed that WT1 and BCR-ABL gene relative expression levels were positively correlated with IL-6 and VEGF levels,and negatively correlated with PC and PS levels(P<0.05).The combined use of WT1 and BCR-ABL genes has higher diagnostic efficacy for MPN than single indicators,with an area under the curve(AUC)of 0.833 and a sensitivity of 88.69%.Conclusion The relative expression levels of WT1 and BCR-ABL genes are correlated with IL-6,VEGF,PC,and PS levels in MPN patients.The combination of WT1 and BCR-ABL genes can effec-tively diagnose MPN.
