Correlation and prognostic analysis of PRDX 4 with cervical lymph node metastasis in oral squamous cell carcinomas
10.3969/j.issn.1671-8348.2025.06.002
- VernacularTitle:过氧化物还原酶4与口腔鳞状细胞癌颈部淋巴结转移的相关性及预后分析
- Author:
Limei WANG
1
;
Sujuan ZHOU
;
Yun CHEN
;
Ke ZHENG
Author Information
1. 宁德师范学院附属宁德市医院病理科,福建 宁德 352100
- Keywords:
oral squamous cell carcinoma;
cervical lymph node metastasis;
depth of tumor infiltration;
peroxidase reductase 4;
survial nanlysis
- From:
Chongqing Medicine
2025;54(6):1286-1292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Explore the effect of expression of peroxidase reductase 4(PRDX4)on cervi-cal lymph node metastasis in oral squamous cell carcinomas(OSCC)and its relationship with prognosis.Methods Using bioinformatics databases to explore the expression,prognosis analysis,and related pathway prediction of PRDX4 gene in head and neck squamous cell carcinoma.At the same time,clinical and pathologi-cal data including cervical lymph node metastasis were collected from 124 OSCC patients,the expression of PRDX4 was detected in 124 OSCC tissues using immunohistochemical experimental methods.Results Analy-sis of online bioinformatics databases showed that PRDX4 was highly expressed in head and neck squamous cell carcinoma and significantly correlated with tumor grade.The immunohistochemical results showed that the occurrence of cervical lymph node metastasis was significantly correlated with the intensity of PRDX4 stai-ning in 124 OSCC cases studied,and high expression of PRDX4 was an independent risk factor for cervical lymph node metastasis in OSCC(P=0.010).The staining intensity of PRDX4 was significantly correlated with the presence of multiple lymph node metastasis(P=0.020)and the the maximum diameter of lymph node metastasis(P=0.031),but not related to the invasion of lymph nodes outside the membrane.Survival a-nalysis showed that strong PRDX4 positivity was significantly correlated with poor disease-free survival(DFS)rate and overall survival(OS)rate in OSCC patients.Conclusion OSCC patients with strong expres-sion of PRDX4 have a higher incidence of cervical lymph node metastasis and a poorer prognosis.
