Relevant research on matrix metalloproteinases in the progression of pancreatic cancer
10.3969/j.issn.1671-8348.2025.05.037
- VernacularTitle:基质金属蛋白酶在胰腺癌进展中作用的研究进展
- Author:
Hongli QIAO
1
;
Zhanyu SONG
;
Jianguo ZHAO
Author Information
1. 内蒙古医科大学附属医院肝胆胰脾外科,呼和浩特 010050
- Keywords:
pancreatic cancer;
matrix metalloproteinases;
tumor microenvironment;
progress;
treatment
- From:
Chongqing Medicine
2025;54(5):1250-1254
- CountryChina
- Language:Chinese
-
Abstract:
The key to the growth and metastasis of pancreatic ductal adenocarcinoma(PDAC)is its complex stromal microenvironment and significant cellular and spatial heterogeneity.It can utilize the interac-tion between cellular and non cellular components in the microenvironment to induce immune escape and drug resistance,thereby reducing patient survival rates.In recent years,relevant studies have revealed the presence of non cellular components in the tumor microenvironment-matrix metalloproteinases(MMP),which can par-ticipate in inflammatory responses and cancer development by hydrolyzing the extracellular matrix.This arti-cle reviews the role of several MMP in the progression of pancreatic cancer,which have been confirmed by pre-vious studies.At the same time,MMP that may be associated with pancreatic cancer,but whose specific mech-anism has not yet been clarified are discussed in depth,providing a basic theoretical basis for further research on MMP as therapeutic targets for pancreatic cancer.
