Research progress of macrophage polarization in odontogenic infectious diseases
10.3969/j.issn.1671-8348.2025.05.036
- VernacularTitle:巨噬细胞极化在牙源性感染性疾病中作用的研究进展
- Author:
Ran DENG
1
;
Xiaowei JI
;
Yi WEI
;
Jin ZHAO
Author Information
1. 新疆医科大学第一附属医院(附属口腔医院)牙体牙髓病科,乌鲁木齐 830054
- Keywords:
odontogenic infection;
macrophages;
M1/M2 polarization;
oral inflammatory diseases;
review
- From:
Chongqing Medicine
2025;54(5):1245-1249
- CountryChina
- Language:Chinese
-
Abstract:
Oral inflammatory diseases caused by odontogenic infections cover a wide range and have a high incidence rate,which can affect the morphology and function of the maxillofacial area and seriously en-danger oral health.Macrophages are important immunoactive cells in oral tissues,which can be polarized into M1/M2 type in different microenvironments,and then exert pro-inflammatory or anti-inflammatory effects,and are widely involved in the progression of odontogenic infectious diseases.In infections caused by oral mi-crobial factors such as bacteria,the distribution characteristics and polarization direction of macrophages in tis-sues are specific.At present,the research on macrophage polarization-related inflammatory diseases has attrac-ted more and more attention,and the regulation of macrophage M1/M2 polarization is gradually being used in the treatment of related diseases,and many research progress has been made in the diagnosis and treatment of odontogenic infectious diseases.In this paper,we elaborate on the distribution characteristics,polarization trends and related applications of macrophage polarization in common oral inflammatory diseases such as pul-pitis,apical periodontitis,periodontitis and peri-implantitis which are mainly caused by dental infections.The aim is to provide new ideas and targets for the diagnosis and treatment of oral inflammatory diseases.
