The role of human aldehyde dehydrogenase gene family in health and disease
10.3969/j.issn.1671-8348.2025.05.035
- VernacularTitle:人类醛脱氢酶基因家族在健康和疾病中的作用
- Author:
Jingfei LI
1
;
Rong LUO
Author Information
1. 重庆医科大学附属第一医院健康管理中心,重庆 400016
- Keywords:
aldehyde dehydrogenase;
retinal;
aromatic aldehydes;
aldehyde detoxification;
cell protection
- From:
Chongqing Medicine
2025;54(5):1240-1244
- CountryChina
- Language:Chinese
-
Abstract:
Human aldehyde dehydrogenase(ALDH)gene family contains 19 functional members,which encode a class of nicotinamide adenine dinucleotide(NAD+)or nicotinamide adenine dinucleotide phos-phate(NADP+)dependent isoenzymes.Their primary function is to oxidise various aldehydes to the corre-sponding carboxylic acids,and act in a variety of pathways:ALDH 1 is used to transmit retinoic acid signals,ALDH2 is used for ethanol detoxification,ALDH1A1 and ALDH3A1 are used to maintain cellular homeosta-sis in the eye,ALDH4A1 participates in amino acid metabolism,ALDH2 and ALDH5A1 participate in the construction of neuronal function,ALDH1L participates in folate metabolism,etc.Mutations in the ALDH gene causing deletion of the ALDH enzyme or abnormal catalytic activity have been associated with a multi-tude of diseases,including type Ⅱ hyperprolainemia,Sj?gren-Larsson syndrome,γ-hydroxybutyric aciduria,cancer,cardiovascular disease,etc.This review provides a detailed and comprehensive overview of the 13 mem-bers belonging to the ALDH gene family that have been investigated in health and disease,focusing on their physiological and pathological functions.
