Research progress on mechanisms related to hypoxia in Alzheimer's disease
10.3969/j.issn.1671-8348.2025.05.034
- VernacularTitle:阿尔茨海默病中缺氧相关机制的研究进展
- Author:
Jing LI
1
;
Xi CHEN
;
Weidong LE
Author Information
1. 电子科技大学医学院,成都 610054
- Keywords:
Alzheimer's disease;
hypoxia;
β-amyloid protein;
Tau protein;
hypoxia inducible factor;
neuroinflammation;
mitochondrial dysfunction;
oxidative stress
- From:
Chongqing Medicine
2025;54(5):1235-1239
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a common degenerative disease of the central nervous system that gradually worsens,characterized by memory loss and cognitive decline,and the condition worsens over time.The pathogenesis of AD is currently unclear,but known evidence suggests that a combination of genetic,environmental,and lifestyle factors can lead to the occurrence and development of AD.Recent studies have shown that hypoxia may be an important risk factor for inducing AD.Under low oxygen conditions,abnormal accumulation of β-amyloid(Aβ)and Tau proteins in the brain can accelerate the progression of AD.In addi-tion,hypoxia can promote the release of inflammatory mediators,intensify the inflammatory response in the brain,and damage nerve cells.Further hypoxia may also affect the blood flow and nutrient supply to the brain,thereby damaging the vascular health of the brain and accelerating the process of neurodegeneration.This arti-cle focuses on the molecular mechanisms related to hypoxia in AD,aiming to further deepen people's under-standing of the relationship between hypoxia and AD,and contribute to the development of new disease treat-ment strategies.
