Progress of ornithine aminotransferase studies
10.3969/j.issn.1671-8348.2025.05.033
- VernacularTitle:鸟氨酸氨甲酰基转移酶生物学特征的研究进展
- Author:
Wenjing WU
1
;
Wenqi ZHAO
;
Erlong ZHANG
;
Jian CHEN
;
Yuqi GAO
;
Zhiqi GAO
Author Information
1. 陆军军医大学高原军事医学系高原特需药品与器材研究室,重庆 400038;高原医学研究中心/高原高寒医学保障重点实验室,重庆 400038
- Keywords:
ornithine transcarbamylase;
ornithine;
citrulline;
urea cycle;
ornithine transcarbamylase de-ficiency
- From:
Chongqing Medicine
2025;54(5):1230-1234
- CountryChina
- Language:Chinese
-
Abstract:
Ornithine transcarbamylase(OTC)is a member of the transcarbamylase protein family,commonly found in the mitochondrial matrix of living organisms.It generally functions in a trimeric form and can catalyze the production of L-ornithine to L-citrulline.OTC is mainly expressed in the liver and intestines of mammals,playing an important role in the urea cycle and amino acid homeostasis.This article introduces the research progress of OTC genes,proteins,physiological functions,the impact of OTC deficiency on body health,and the diagnosis and treatment of OTC deficiency.
