Study on the predictive value of heparin-binding protein combined with soluble growth-stimulating expression gene 2 protein for the prognosis of elderly patients with acute heart failure
10.3969/j.issn.1671-8348.2025.05.022
- VernacularTitle:肝素结合蛋白联合可溶性生长刺激表达基因2蛋白对老年急性心力衰竭患者预后的预测价值研究
- Author:
Weilei WANG
1
;
Fei WANG
;
Shanshan SHENG
;
Dong WANG
;
Houqing WANG
Author Information
1. 徐州医科大学附属医院急诊医学科,江苏徐州 221000
- Keywords:
heart failure;
biomarkers;
heparin-binding proteins;
soluble growth-stimulation expression gene 2 protein;
major adverse cardiovascular events
- From:
Chongqing Medicine
2025;54(5):1166-1171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of heparin-binding protein(HBP)combined with soluble growth-stimulated gene 2 protein(sST2)for the prognosis of elderly patients with acute heart failure(AHF).Methods A total of 338 elderly AHF patients who were treated in the Affiliated Hospital of Xuzhou Medical University and Kuitun Hospital of Ili Kazakh Autonomous Prefecture from April 2021 to March 2022 were selected as the research subjects.The patients were followed up for 1 year.According to whether the ma-jor adverse cardiovascular and cerebrovascular events(MACE)occurred during the follow-up period,they were divided into the MACE group and the non-MACE group,respectively.The baseline characteristics of the patients were recorded,laboratory indicators were detected,transthoracic color Doppler ultrasound examina-tion was completed,the risk factors affecting the prognosis of elderly patients with AHF,as well as the predic-tive value of HBP and sST2 for the prognosis of elderly patients with AHF were analyzed.Results Among the 338 elderly AHF patients,101 patients experienced MACE,and 237 patients did not.The levels of serum creatinine,NT-proBNP,troponin T,white blood cell count(WBC),left ventricular end-diastolic diameter(LVEDD),HBP,and sST2 in the MACE group were higher than those in the non-MACE group,while the left ventricular ejection fraction(LVEF)was lower than that in the non-MACE group,and the differences were statistically significant(P＜0.05).LVEF was a protective factor for the occurrence of MACE(HR＜1,P＜0.05)and age,diabetes mellitus,creatinine,NT-proBNP,troponin T,LVEF,WBC,HBP,and sST2(HR≥1,P＜0.05)were the influencing factors for the occurrence of MACE.The optimized model(Model 5)has the highest predictive efficiency for the prognosis of elderly patients with AHF,with an area under the curve(AUC)of 0.976(95％CI:0.962-0.990).Conclusion Both HBP and sST2 are independent risk factors for the occurrence of MACE in elderly AHF patients.The predictive model established by combining HBP and sST2 has a high predictive value.
