Correlation between serum adipokine levels and insulin resistance in preterm infants with extrauterine growth retardation
10.3969/j.issn.1671-8348.2025.05.013
- VernacularTitle:宫外生长迟缓早产儿血清脂肪因子水平与胰岛素抵抗的相关性研究
- Author:
Yongming WANG
1
;
Jiao YUAN
;
Pengyu ZHANG
;
Jia WANG
;
Sanxiang XUE
Author Information
1. 银川市妇幼保健院新生儿科,银川 750000
- Keywords:
premature infants;
extrauterine growth retardation;
insulin resistance;
adiponectin;
leptin;
resistin
- From:
Chongqing Medicine
2025;54(5):1123-1127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum adipokine levels and insulin resist-ance in preterm infants with early extrauterine growth retardation(EUGR).Methods A total of 130 preterm infants admitted to the neonatal intensive care unit of the hospital from March 2023 to March 2024 were se-lected as the research subjects.They were divided into the EUGR group(n=63)and the non-EUGR group(n=67)based on whether their weight Z-score at 2 weeks of age was ≥-1.28.Clinical data of the preterm infants and their mothers were collected.Blood samples were collected at 14 days after birth to measure serum insulin,adiponectin,resistin,leptin,blood glucose,total cholesterol,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),and triglyceride levels.The homeostasis model assessment of insulin resistance(HOMA-IR)was calculated,and the correlation between HOMA-IR and adipokine levels as well as lipid levels was analyzed.Results Compared with the non-EUGR group,the EUGR group had a high-er proportion of mothers with pregnancy-induced hypertension.The preterm infants in the EUGR group had higher levels of insulin,resistin,leptin,triglycerides,and HOMA-IR,and lower levels of HDL-C,with statisti-cally significant differences(P＜0.05).In the EUGR group,HOMA-IR was positively correlated with adi-ponectin,resistin,and leptin levels,while in the non-EUGR group,HOMA-IR was positively correlated with adiponectin levels(P＜0.05).Conclusion Insulin resistance in preterm infants with early EUGR may be re-lated to changes in adipokine levels.
