Application value of small airway function measurement in children with cough variant asthma
10.3969/j.issn.1671-8348.2025.05.010
- VernacularTitle:咳嗽变异性哮喘患儿小气道对支气管激发试验的反应性分析
- Author:
Hongjia CHEN
1
;
Tao AI
;
Ronghua LUO
;
Li WANG
;
Wenwen CHEN
Author Information
1. 电子科技大学医学院附属妇女儿童医院·成都市妇女儿童中心医院儿童呼吸科,成都 611731
- Keywords:
bronchial provocation test;
cough variant asthma;
children;
small airway function;
chronic cough
- From:
Chongqing Medicine
2025;54(5):1107-1110,1117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of small airway function measurement in chil-dren with cough variant asthma(CVA).Methods A total of 155 children with chronic cough who visited the hospital from January to December 2022 were selected as the research subjects and divided into the CVA group(n=78)and the non-CVA group(n=77)according to the results of the bronchial provocation test.The small airway function was evaluated by three indicators in the basic lung function:the percentage of the maximum mid-expiratory flow to the predicted value(MMEF％pred),and the percentage of the instantaneous expiratory flow to the predicted value when forcefully exhaling 50％and 75％of the vital capacity(FEF50％％pred,FEF75％％ pred).If any one of the three indicators is lower than the lower limit of the normal value(＜65％),it is determined as small airway dysfunction.The incidence of small airway dysfunction and the indica-tors of atmospheric airway function[percentage of forced expiratory volume in one second to the predicted value(FEV1％pred),percentage of maximum expiratory flow to the predicted value(PEF％ pred)]and small airway(MMEF％pred,FEF50％％pred,FEF75％％)before and after bronchial provocation tests were compared between the two groups.Results Among 55 children with chronic cough,47 cases were found to have small airway dysfunction,with 33 cases in the CVA group and 14 cases in the non-CVA group.The incidence of small airway dysfunction in the CVA group was higher than that in the non-CVA group[42.3％(33/78)vs.18.2％(14/77)],and the difference was statistically significant(P＜0.05).Compared with before the bron-chial provocation test,the levels of large and small airway function indicators in both groups decreased after the bronchial provocation test.The decrease rate in the CVA group was higher than that in the non-CVA group,and the decrease rates of MMEF％pred,FEF50％％pred,and FEF75％％ pred were higher than those of FEV1％ pred and PEF％ pred,the differences were statistically significant(P＜0.05).Conclusion Small air-way function measurement can be performed in children with CVA for early diagnosis and therapeutic effect e-valuation.
