Analysis of influencing factors of individual efficacy differences of dapagliflozin in the treatment of patients with type 2 diabetes mellitus
10.3969/j.issn.1671-8348.2025.05.005
- VernacularTitle:达格列净治疗2型糖尿病患者个体疗效差异的影响因素分析
- Author:
Weina LIN
1
;
Ya CHEN
;
Yongru ZHUANG
;
Fen XIE
;
Jinfang SONG
Author Information
1. 江南大学附属医院药学部,江苏无锡 214000
- Keywords:
genetic pharmacology;
type 2 diabetes mellitus;
dapagliflozin;
PPARD;
insulin resistance
- From:
Chongqing Medicine
2025;54(5):1074-1079
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influence of clinical indicators and PPARD gene polymorphism on the hypoglycemic efficacy of dapagliflozin(DAPA)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 102 patients with T2DM who visited the Affiliated Hospital of Jiangnan University and the Affiliated Hospital of Xuzhou Medical University from June 2021 to December 2023 were selected as the study subjects,an observational cohort of T2DM patients treated with DAPA was established,and DAPA tablets of 10 mg were administered orally once a day for 12 weeks,the venous blood and clinical data of the patients were col-lected.PPARD gene polymorphism typing was performed by using the Snapshot method.The differences in clinical indicators among patients with different genotypes were compared and the influencing factors of DA-PA in improving insulin resistance index(HOMA-IR)were analyzed.Results Eighty-two patients completed the 12-week follow-up.Before DAPA treatment,the differences in the clinical indicators of patients with dif-ferent PPARD rs3777744 genotypes were not statistically significant(P＞0.05).After 12 weeks of DAPA treatment,compared with patients with AA genotype,patients carried of G allele(GG+AG genotype)had lower levels of fasting blood glucose(FPG),HOMA-IR and its decrease,and the differences were statistically significant(P＜0.05).The results of multiple linear regression analysis showed that the genotype of PPARD rs3777744 locus and baseline HOMA-IR were correlated with the improvement of HOMA-IR after 12 weeks of DAPA treatment,and the improvement of HOMA-IR in G allele carriers was not as significant as that in AA genotype patients,and the higher the baseline HOMA-IR,the more significant the improvement of HO-MA-IR.Conclusion Different genotypes of PPARD rs3777744,baseline HOMA-IR are important influencing factors for DAPA to improve insulin resistance of T2DM patients.
