Research progress on the role of inflammation in post-stroke depression and the protective effect of Chinese medicine preparations

VernacularTitle:炎症反应在卒中后抑郁中的作用及中药制剂保护作用的研究进展
Author: Wei LI ¹ ; Ru GUI ; Jingping SUN ; Xueli CAI
Author Information

1. 丽水市中心医院神经内科,浙江丽水 323000;丽水市神经病学临床研究中心,浙江丽水 323000
Keywords: post-stroke depression; inflammation; mechanism of action; Chinese medicine preparation
From: Chongqing Medicine 2025;54(4):1000-1004
CountryChina
Language:Chinese
Abstract: Inflammation plays a crucial role in the occurrence and development of post-stroke depres-sion(PSD),yet the specific molecular mechanisms are still not fully understood.In the field of drug research,traditional Chinese medicine preparations have attracted increasing attention for improving PSD symptoms due to their advantages of multiple targets,many links,and few side effects.At the same time,they have great re-search value in the prevention and treatment of PSD.This article reviews the mechanism of inflammatory re-action,such as the balance regulation of pro-inflammatory/anti-inflammatory factors,inflammatory markers,gene polymorphism of inflammatory factors in PSD,and the related research progress of Chinese medicine preparations in regulating inflammatory reaction to prevent and treat PSD,with a view to providing reference for the selection of clinical Chinese medicine preparations and the prevention and treatment of PSD.