Research progress on the role of ferroptosis in ulcerative colitis
10.3969/j.issn.1671-8348.2025.04.036
- VernacularTitle:铁死亡在溃疡性结肠炎中作用的研究进展
- Author:
Jiayang ZENG
1
;
Shuimei CEN
;
Tong HUANG
;
Honggang CHI
Author Information
1. 广东医科大学附属东莞第一医院,广东东莞 523000
- Keywords:
ulcerative colitis;
ferroptosis;
intestinal inflammation;
intestinal barrier;
gut microbiota
- From:
Chongqing Medicine
2025;54(4):995-999
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis(UC)is an inflammatory disease with unclear etiology and pathogenesis.In recent years,with the continuous in-depth research on the pathology of UC,it has been discovered that there exists a new form of cell death in the pathological process of UC,namely ferroptosis.A series of pathological changes closely related to ferroptosis in the pathological tissues of UC patients.This article aims to investigate the role of ferroptosis in the pathogenesis of UC,and introduce the relationship between UC and ferroptosis from the aspects of inflammation,intestinal mucosal barrier and intestinal flora,as well as the recent research progress in this field.
