Research progress on recombinant human DNA damage induced transcription factor 4 in malignant tumors
10.3969/j.issn.1671-8348.2025.04.032
- VernacularTitle:重组人DNA损伤诱导转录因子4在恶性肿瘤中的研究进展
- Author:
Shuyun CAO
1
;
Jishi WANG
Author Information
1. 贵州医科大学附属医院,贵阳 550004;贵州医科大学,贵阳 550004
- Keywords:
DNA damage-inducible transcript 4;
malignant tumor;
tumor microenvironment;
autoph-agy;
drug resistance
- From:
Chongqing Medicine
2025;54(4):972-976
- CountryChina
- Language:Chinese
-
Abstract:
DNA damage-inducible transcript 4(DDIT4)is a gene activated under stress conditions,par-ticipating in cell growth,apoptosis,metabolism,and oxidative stress.In recent years,significant progress has been made in the research on the mechanism of DDIT4 in tumorigenesis and development.It has been con-firmed that it is involved in regulating processes such as apoptosis,proliferation,migration and invasion of tumor cells,and is also involved in multiple key biological processes such as tumor microenvironment remode-ling,autophagy regulation and drug resistance formation.Targeting DDIT4 may potentially become an effec-tive therapeutic option for inhibiting the tumorigenesis and tumour progression.Targeting DDIT4 is expected to be an effective therapeutic option to inhibit the tumorigenesis and progression.This article reviews the research progress on the role and regulatory mechanisms of DDIT4 in cancer.
