Research progress of neurodevelopmental disorders in intrauterine growth restriction
10.3969/j.issn.1671-8348.2025.04.031
- VernacularTitle:宫内生长受限胎儿神经发育障碍的研究进展
- Author:
Tingting YIN
1
;
Jun YAN
;
Qiuqin TANG
;
Hongjuan DING
Author Information
1. 南京医科大学附属妇产医院/南京市妇幼保健院产科,南京 210004
- Keywords:
intrauterine growth restriction;
neurodevelopmental disorders;
neonatal brain injury;
molec-ular indicator;
child
- From:
Chongqing Medicine
2025;54(4):966-971
- CountryChina
- Language:Chinese
-
Abstract:
Intrauterine growth restriction(IUGR),which refers to the failure of the fetus to achieve ad-equate growth potential,is a common complication of pregnancy.The disease seriously affects fetal growth and development,increases the risk of fetal and neonatal complications and death,and easily causes adverse perina-tal outcomes such as fetal distress and neonatal asphyxia.Children with IUGR have a high risk of lifelong neu-rodevelopmental consequences such as cognitive deficits,cerebral palsy,behavioral problems,learning and con-centration difficulties.Currently,there is no definite treatment method to protect neonates with IUGR from adverse neurological consequences.Early and accurate identification and intervention to promote neurodevelop-ment are essential to improve poor outcomes in neonates with IUGR.In addition,IUGR can also affect blood flow in the fetal brain,change the structure of the ventricles,affect brain functions and change molecular dy-namics indicators in the brain.The purpose of this article is to summarize the progress of research on fetal neurodevelopment of IUGR in recent years,and to review how IUGR affects fetal neurodevelopment and the corresponding diagnostic monitoring methods,so as to provide new ideas for further determining the plan to improve the long-term poor neurological prognosis.
