Research progress of bone marrow mesenchymal stem cell transplantation in the treatment of diabetes related complications
10.3969/j.issn.1671-8348.2025.04.030
- VernacularTitle:骨髓间充质干细胞移植对糖尿病相关并发症治疗作用的研究进展
- Author:
Yifei LIAO
1
;
Yu ZHANG
;
Jiang MING
;
Yidong LIAO
Author Information
1. 贵州医科大学附属医院影像科,贵阳 550004;贵州医科大学,贵阳 561113
- Keywords:
bone marrow mesenchymal stem cells;
immune regulation;
tunneling nanotubes;
diabetes cardiomyopathy;
diabetes nephropathy;
diabetes retinopathy
- From:
Chongqing Medicine
2025;54(4):960-965
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus(DM)is a systemic endocrine disease associated with a disorder or defi-ciency of glucose metabolism caused by the obstruction or lack of insulin resistance.Conventional drugs for the treatment of DM have limited efficacy for its complications,and there are many drugs side effects,so it is urgent to find innovative and efficient treatment methods.Mesenchymal stem cells(MSCs)have multiple dif-ferentiation potentials,can reduce insulin resistance,promote microvascular repair,improve oxidative stress and inhibit fibrosis,and can also regulate the immune microenvironment in the body.They can also be trans-ferred to the spleen to regulate the immune microenvironment in vivo and transplant healthy mitochondria to restore the function of damaged cells,among other properties,which hold great promise for the treatment of DM complications.This article briefly reviews the current treatment and pathophysiological mechanisms of MSCs on various complications caused by DM,which is expected to provide a reference and theoretical basis for the clinical treatment of DM in the future.
