Functional near-infrared spectroscopy study of cerebral hemodynamics in major depressive disorder with versus without psychotic symptoms
10.3969/j.issn.1671-8348.2025.04.028
- VernacularTitle:伴与不伴精神病性症状的抑郁症患者近红外脑功能成像研究
- Author:
Youyou GUO
1
;
Yanjie YU
;
Hui WEN
;
Hongyan CHEN
;
Xuemei LI
Author Information
1. 重庆医科大学附属第一医院精神科重大脑疾病与衰老教育部重点实验室,重庆 400016
- Keywords:
functional near-infrared spectroscopy;
major depressive disorder;
psychotic features;
oxy-genated hemoglobin;
verbal fluency task
- From:
Chongqing Medicine
2025;54(4):949-953
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate differential patterns of oxygenated hemoglobin concentration in prefron-tal cortical regions between major depressive disorder patients with or without psychotic symptoms during verbal flu-ency task(VFT)performance using functional near-infrared spectroscopy(fNIRS).Methods A total of 108 pa-tients with major depression who were hospitalized in the psychiatric department of the hospital from July 2023 to April 2024 were selected as the study objects.They were divided into two groups(n=60)with or without psychotic symptoms(n=48).fNIRS devices were used to measure and compare the changes in the relative concentration of cerebral hemoglobin in 52 brain channels between the two groups during VFT.Re-sults Compared with the unaccompanied group,the relative concentration of cerebral oxygenated hemoglobin in channel 13 was higher(0.003±0.001 vs.0.002±0.001),and the relative concentration of cerebral oxygen-ated hemoglobin in channel 33 was lower(0.003±0.001 vs.0.007±0.002),the difference was statistically significant(P＜0.05).There was no significant difference in the relative concentration of oxygenated hemo-globin in other brain areas between the two groups(P＞0.05).Conclusion There are abnormal oxygen activ-ity in brain functional areas associated with psychotic symptoms,and fNIRS technique is helpful for early as-sessment of cerebral aerobic function in depressed patients with psychotic symptoms.
